Polymorphisms of DNA repair genes XRCC1 and LIG4 and idiopathic male infertility
نویسندگان
چکیده
منابع مشابه
Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG)
PURPOSE Oxidative DNA damage has been shown to have some role in the development of primary open angle glaucoma (POAG). In this study, we aimed to determine the frequency of polymorphisms in two DNA repair enzyme genes, Xeroderma pigmentosum complementation group D (XPD) codon 751 and X-ray cross-complementing group 1 (XRCC1) codon 399, in a sample of Turkish patients with POAG, and to evaluate...
متن کاملPolymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer.
Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are two major DNA base excision repair (BER) proteins and act interactively in stimulating and executing BER processes. Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Gln have been associated with altered protein function and BER activity. This case-control study examined the contribution of these...
متن کاملPolymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk.
XRCC1 (X-ray cross-complementing group 1) and ERCC2 (excision repair cross-complementing group 2) are two major DNA repair proteins. Polymorphisms of these two genes have been associated with altered DNA repair capacity and cancer risk. We have described statistically significant interactions between the ERCC2 polymorphisms (Asp312Asn and Lys751Gln) and smoking in lung cancer risk. In this case...
متن کاملPolymorphisms in the DNA repair gene XRCC1 and breast cancer.
X-ray repair cross complementing group 1 (XRCC1) encodes a protein involved in base excision repair. We examined the association of polymorphisms in XRCC1 (codon 194 Arg-->Trp and codon 399 Arg-->Gln) and breast cancer in the Carolina Breast Cancer Study, a population-based case-control study in North Carolina. No association was observed between XRCC1 codon 194 genotype and breast cancer, and ...
متن کاملPolymorphisms in two DNA repair genes (XPD and XRCC1) – association with age related cataracts
PURPOSE Age related cataract is the leading cause of blindness in the world today. The association between DNA damage to the lens epithelium and the development of lens opacities has been reported in many studies. Polymorphisms of DNA repair enzymes may affect repair efficiency and thereby lead to the development of age related cataract. METHODS In this study, we aimed to determine the freque...
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ژورنال
عنوان ژورنال: Systems Biology in Reproductive Medicine
سال: 2017
ISSN: 1939-6368,1939-6376
DOI: 10.1080/19396368.2017.1374488